CB1R mostly resides in the central nervous system (CNS) while the CB2R receptors are mostly expressed in the immune cells such as natural killer cells, neutrophils, and monocytes as well as other tissues such as the bladder, intestine, etc
Studies have shown positive results indicating that GLP-1 or its analog can reduce hepatic gluconeogenesis and lipogenesis, suggesting that GLP-1 can be used in the treatment of NASH 29,30,31
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The evolutionary origin of exendin genes ( exendin 14) has not been fully resolved but it seems likely that exendins evolved by duplication from a glucagon-like peptide gene precursor 14